Drug resistance is uncommon in pregnant women with low viral loads taking zidovudine monotherapy to prevent perinatal HIV transmission

被引：18
|
作者：
Larbalestier, N [1 ]
Mullen, J
O'Shea, S
Cottam, F
Sabin, CA
Chrystie, AL
Welche, J
Zuckerman, M
Hay, P
Rice, P
Taylor, GP
Ruiter, AC
机构：
[1] Guys Kings & St Thomas Sch Med, Dept Genitourinary Med, Virol Sect, London SE1 7EH, England
[2] Guys Kings & St Thomas Sch Med, Dept Infect, Virol Sect, London SE1 7EH, England
[3] Guys & St Thomas Hosp Trust, Dept Infect, Virol Sect, London SE1 7EH, England
[4] UCL Royal Free & Univ Coll, Sch Med, Dept Primary Care & Populat Sci, HIV Res Unit, London NW3 2PF, England
[5] Kings Coll London, Dept Genitourinary Med, London SE5 9RS, England
[6] Kings Coll Hosp London, Dulwich Hosp, Guys Kings & St Thomas Sch Med, Dept Virol,Dept Infect, London, England
[7] Kings Coll Hosp London, Dulwich Hosp, Guys Kings & St Thomas Sch Med, Dept Virol,S London Publ Hlth Lab, London, England
[8] Univ London St Georges Hosp, Dept Genitourinary Med, London SW7 0QT, England
[9] Univ London St Georges Hosp, Dept Virol, London SW7 0QT, England
[10] Univ London Imperial Coll Sci Technol & Med, Sch Med St Marys, London, England
来源：
AIDS | 2003年 / 17卷 / 18期
关键词：
D O I：
10.1097/00002030-200312050-00015
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Zidovudine monotherapy is used to reduce perinatal HIV transmission in women with low viral loads. There are few data on the risk of drug resistance in this select cohort of women. We determined the prevalence of newly acquired mutations conferring reduced sensitivity to zidovudine after exposure during pregnancy, and found that the development of mutations was uncommon and was restricted to women treated before 1998 who had higher baseline viral loads than those currently recommended monotherapy.
引用
收藏
页码：2665 / 2667
页数：3
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