Clinical significance and effect of Sam68 expression in gastric cancer

被引：11

作者：

Xiao, Jinzhang ^{[1
]}

Wang, Qiuhong ^{[1
]}

Yang, Qichang ^{[2
]}

Wang, Hua ^{[2
]}

Qiang, Fulin ^{[1
]}

He, Song ^{[1
]}

Cai, Jin ^{[1
]}

Yang, Lei ^{[1
]}

Wang, Yingying ^{[2
]}

机构：

[1] Affiliated Nantong Canc Hosp, Dept Internal Oncol Med, Nantong 226000, Jiangsu, Peoples R China

[2] Nantong Univ, Jiangsu Prov Key Lab Inflammat & Mol Drug Target, 19 Qixiu Rd, Nantong 226000, Jiangsu, Peoples R China

来源：

ONCOLOGY LETTERS | 2018年 / 15卷 / 04期

关键词：

gastric cancer; Src-associated in mitosis of 68 kDa; proliferation; migration; metastasis; SPLICING REGULATOR SAM68; RNA-BINDING; TRANSCRIPTIONAL ACTIVITY; PROTEIN; CELLS; PROLIFERATION; ADIPOGENESIS; SURVIVAL;

D O I：

10.3892/ol.2018.7930

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric cancer is one of the most common types of malignancy worldwide. However, the molecular mechanisms of cancer development remain unclear. Src-associated in mitosis of 68 kDa (Sam68) is involved in cell proliferation, transformation, tumorigenesis and metastasis in several types of cancer. The present study aimed to assess the expression and function of Sam68 in human gastric cancer. Western blot analysis and immunohistochemistry indicated that Sam68 expression was increased in tumor samples and the levels were associated with the grade of malignancy. High Sam68 expression was associated with the poor prognosis of patients with gastric cancer. In vitro, following knockdown of Sam68 by transfection of gastric cancer cells with small interfering RNA, the cell viability, cell cycle progress, migration and invasion were decreased. The results of the present study revealed that Sam68 may be a novel prognostic factor for, and is associated with cell growth, migration and invasion in, gastric cancer.

引用

页码：4745 / 4752

页数：8

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