Decreased Activity and Stability of Pyruvate Kinase in Hereditary Hemolytic Anemia: A Potential Target for Therapy By AG-348 (Mitapivat), an Allosteric Activator of Red Blood Cell Pyruvate Kinase

被引：11
|
作者：
Rab, Minke A. E. [1 ,2 ]
van Oirschot, Brigitte A. [2 ]
van Straaten, Stephanie [3 ]
Biemond, Bart J. [4 ]
Bos, Jennifer [2 ]
Kosinski, Penelope A. [5 ]
Kung, Charles [5 ]
van Beers, Eduard J. [1 ]
van Wijk, Richard [6 ]
机构：
[1] Univ Utrecht, UMC Utrecht, Creveldklin, Utrecht, Netherlands
[2] Univ Utrecht, Dept Clin Chem & Haematol, UMC Utrecht, Utrecht, Netherlands
[3] Elisabeth TweeSteden Hosp, Dept Pediat, Tilburg, Netherlands
[4] Acad Med Ctr, Dept Clin Hematol, Amsterdam UMC, Amsterdam, Netherlands
[5] Agios Pharmaceut Inc, Cambridge, MA USA
[6] Univ Med Ctr Utrecht, Lab Clin Chem & Hematol, Utrecht, Netherlands
来源：
BLOOD | 2019年 / 134卷
关键词：
D O I：
10.1182/blood-2019-129996
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
3506
引用
收藏
页数：4
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