Gold-Catalyzed Direct Alkynylation of Azulenes

被引：37
|
作者：
Szekely, Anna [1 ]
Peter, Aron [1 ]
Aradi, Klara [1 ]
Tolnai, Gergely L. [2 ]
Novak, Zoltan [1 ]
机构：
[1] Eotvos Lorand Univ, Inst Chem, MTA ELTE Lendulet Catalysis & Organ Synth Res Grp, Pazmany Peter Stny 1-A, H-1117 Budapest, Hungary
[2] Eotvos Lorand Univ, Inst Chem, Pazmany Peter Stny 1-A, H-1117 Budapest, Hungary
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 04期
关键词：
EXPANSION-ANNULATION STRATEGY; CROSS-COUPLING REACTION; DIRECT ARYLATION; DIARYLIODONIUM SALTS; CONJUGATED OLIGOMERS; SUBSTITUTED AZULENES; 2+2 CYCLOADDITION; REDOX BEHAVIOR; VINYL ETHER; EASY ACCESS;
D O I：
10.1021/acs.orglett.7b00259
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel catalytic method for the direct C-H alkynylation of azulenes is developed. The gold catalyzed functionalization of this special carbacycle is achieved with hypervalent iodonium reagent TIPS-EBX under mild reaction conditions. With the aid of the developed procedure, several TIPS alkynylated azulene derivatives were synthesized bearing important functional groups for further functionalization.
引用
收藏
页码：954 / 957
页数：4
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