Tenogenic differentiation of mesenchymal stem cells and noncoding RNA: From bench to bedside

被引：6

作者：

Lu, Ying-fei ^{[1
,2
]}

Chan, Kai-ming ^{[1
,2
,3
]}

Li, Gang ^{[1
,2
,3
]}

Zhang, Jin-fang ^{[1
,2
,3
]}

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Orthopaed & Traumatol, Room 904,9-F, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Fac Med, Lui Che Woo Inst Innovat Med, Room 904,9-F, Shatin, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Stem Cells & Regenerat Med Lab, Room 904,9-F, Shatin, Hong Kong, Peoples R China

来源：

EXPERIMENTAL CELL RESEARCH | 2016年 / 341卷 / 02期

关键词：

Tendon; Tendon differentiation; Tendon-derived stem cells; Non-coding RNAs; TENDON STEM/PROGENITOR CELLS; ACHILLES-TENDON; IN-VITRO; GENE-EXPRESSION; MECHANICAL STIMULATION; EXTRACELLULAR-MATRIX; SIGNALING PATHWAY; FIBROBLAST-GROWTH; GDF-5; DEFICIENCY; TENDINOPATHY;

D O I：

10.1016/j.yexcr.2015.12.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tendon is a critical unit of musculoskeletal system that connects muscle to bone to control bone movement. More population participate in physical activities, tendon injuries, such as acute tendon rupture and tendinopathy due to overuse, are common causing unbearable pain and disability. However, the process of tendon development and the pathogenesis of tendinopathy are not well defined, limiting the development of clinical therapy for tendon injuries. Studying the tendon differentiation control pathways may help to develop novel therapeutic strategies. This review summarized the novel molecular and cellular events in tendon development and highlighted the clinical application potential of non coding RNAs and tendon-derived stem cells in gene and cell therapy for tendon injuries, which may bring insights into research and new therapy for tendon disorders. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：237 / 242

页数：6

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