Hippo pathway deregulation: implications in the pathogenesis of haematological malignancies

被引：3

作者：

Cacemiro, Maira da Costa ^{[1
]}

Berzoti-Coelho, Maria Gabriela ^{[1
]}

Cominal, Jucara Gastaldi ^{[1
]}

Burin, Sandra Mara ^{[1
]}

de Castro, Fabiola Attie ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Sao Paulo, Brazil

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2017年 / 70卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

MESSENGER-RNA EXPRESSION; YES-ASSOCIATED PROTEIN; TUMOR-SUPPRESSOR; CELL-PROLIFERATION; DOWN-REGULATION; YAP; APOPTOSIS; DROSOPHILA; GENE; PROMOTES;

D O I：

10.1136/jclinpath-2016-204055

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The Hippo pathway participates in the regulation of cell proliferation, differentiation and apoptosis. It is composed by a large array of proteins whose deregulation has been associated with pro-oncogenic and antioncogenic processes. The present review focuses on the Hippo pathway signalling network and discusses its dual role in oncogenesis, particularly in haematological malignancies.

引用

页码：9 / 14

页数：6

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