This study compared the micro-leakage of a root canal filled with Resilon or gutta-percha (GP), utilizing either cold lateral condensation or System B. Four experimental groups were used. Group one was obturated with GP using cold lateral condensation, group two with GP using System 13, group three with Resilon using cold lateral condensation, and group four with Resilon using System B. Micro-leakage was tested using a two-chamber bacterial method as well as a dye penetration test. Data was subjected to statistical analysis using an ANOVA. A p-value <0.05 was considered as significant. The bacterial micro-leakage test showed no significant difference between GP and Resilon when using Cold Lateral condensation (p = 0.2695) or System B (p = 0.5602). The dye penetration test also showed no significant difference between GP and Resilon using either the Cold Lateral condensation (p = 0.2713) or the System B techniques (p = 0.0767). The ability of GP and Resilon to seal a root canal is similar.