Drugs targeting the renin-angiotensin-aldosterone system

被引：347
|
作者：
Zaman, MA [1 ]
Oparil, S [1 ]
Calhoun, DA [1 ]
机构：
[1] Univ Alabama Birmingham, Vasc Biol & Hypertens Program, Div Cardiovasc Dis, Dept Med, Birmingham, AL 35294 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 08期
关键词：
D O I：
10.1038/nrd873
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Effective antihypertensive therapy has made a major contribution to the reductions in the morbidity and mortality of cardiovascular disease that have been achieved since the 1960s. However, blood-pressure control with conventional drugs has not succeeded in reducing cardiovascular disease risks to levels seen in normotensive persons. Drugs that inhibit or antagonize components of the renin-angiotensin-aldosterone system are addressing this deficiency by targeting both blood pressure and related structural and functional abnormalities of the heart and blood vessels, thus preventing target-organ damage and related cardiovascular events.
引用
收藏
页码：621 / 636
页数：16
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