Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice

被引：0
|
作者：
Asakawa, A
Inui, A
Goto, K
Yuzuriha, H
Takimoto, Y
Inui, T
Katsuura, G
Fujino, MA
Meguid, MM
Kasuga, M
机构：
[1] Kobe Univ, Grad Sch Med, Div Diabet Digest & Kidney Dis, Dept Clin Mol Med,Chuo Ku, Kobe, Hyogo 6500017, Japan
[2] Inui Clin, Osaka 5700011, Japan
[3] Shionogi & Co Ltd, Shionogi Res Labs, Shiga 5203423, Japan
[4] Yamanashi Med Univ, Dept Internal Med 1, Yamanashi 4093898, Japan
[5] SUNY Upstate Med Univ, Dept Surg, Syracuse, NY USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2002年 / 10卷 / 04期
关键词：
agouti-related protein; orexin; melanin-concentrating hormone; arcuate nucleus; lateral hypothalamic area; oxygen consumption; mice;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Neuropeptides in the hypothalamus play a pivotal role in the regulation of energy balance. Agouti-related protein (AGRP), orexin and melanin-concentrating hormone (MCH) have been identified in the hypothalamus as orexigenic peptides. This study was undertaken to investigate the effects of AGRP, orexin and MCH on oxygen consumption. Oxygen consumption was determined by an O-2/CO2 metabolism measuring system at 22degreesC. Mice were kept unrestrained in the chamber without food or water during the light cycle, and the oxygen consumption was measured for 2 h after intra-cerebroventricular (ICV) administration. ICV administered AGRP (1 nmol/mouse) significantly decreased oxygen consumption compared to ACSF-treated controls. Orexin (1 nmol/mouse) significantly increased oxygen consumption, while MCH (1 nmol/mouse) had no significant effect compared to ACSF-treated controls. These results suggest that AGRP, orexin and MCH might have different effects on energy expenditure, thereby regulating appetite and body weight.
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收藏
页码：523 / 525
页数：3
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