A Comprehensive Review of Pediatric Tumors and Associated Cancer Predisposition Syndromes

被引：42
|
作者：
Scollon, Sarah [1 ]
Anglin, Amanda Knoth [2 ]
Thomas, Martha [3 ]
Turner, Joyce T. [4 ]
Schneider, Kami Wolfe [5 ]
机构：
[1] Texas Childrens Hosp, Dept Pediat, Baylor Coll Med, Texas Childrens Canc Ctr, 1102 Bates St,FC 1200, Houston, TX 77030 USA
[2] Myriad Genet Labs, Dayton, OH USA
[3] Univ Virginia, Charlottesville, VA USA
[4] Childrens Natl Med Ctr, Dept Genet & Metab, Washington, DC 20010 USA
[5] Univ Colorado, Childrens Hosp Colorado, Dept Pediat, Ctr Canc & Blood Disorders, Aurora, CO USA
来源：
JOURNAL OF GENETIC COUNSELING | 2017年 / 26卷 / 03期
关键词：
Pediatric cancer predisposition; Genetics; Genetic testing; Tumors; Cancer;
D O I：
10.1007/s10897-017-0077-8
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
An understanding of the role of inherited cancer predisposition syndromes in pediatric tumor diagnoses continues to develop as more information is learned through the application of genomic technology. Identifying patients and their relatives at an increased risk for developing cancer is an important step in the care of this patient population. The purpose of this review is to highlight various tumor types that arise in the pediatric population and the cancer predisposition syndromes associated with those tumors. The review serves as a guide for recognizing genes and conditions to consider when a pediatric cancer referral presents to the genetics clinic.
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页码：387 / 434
页数：48
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