Small businesses have many challenges that must be resolved before adoption of e-procurement systems. The present study aims to understand the various financial, technological, educational, organizational, banking, and customers challenges in the adoption of e-procurement system in SME. Based on these challenges, this study has recommended how SME can adopt e-procurement systems. The study followed an interpretivist approach based on qualitative design using 30 non-directive and semi-structured interviews from the various stakeholders of SME. Results reveal the financial, technological, educational, organizational, banking, and suppliers' challenges in the adoption of e-procurement system. Findings emerged with various themes such as limited financial budget and support, high cybercrime rate and lower level of privacy, lack of e-commerce educational programs, and lower level of learning opportunities. Top management must address employee, financial, organizational, and educational challenges before adoption of e-procurement system in SME.