Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and antihypertensive activity of some 1-[6-(4-alkoxyphenyl)-3-methyl-5,6-dihydro-s-triazolo[3,4-b][1,3,4]thiadiazol-5-yl]-3-(5-aryl-s-triazol-3-ylthio)propan-2-ols

被引：0

作者：

Gupta, R

Sudan, S

Mengi, V

Kachroo, PL

机构：

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1996年 / 35卷 / 06期

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D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-[6-(4-alkoxyphenyl)-3-methyl-5, 6-dihydro-s-triazolo[3,4-b][1, 3, 4]thiadiazol-5-yl]-3-(5-aryl-s-triazol-3-ylthio)propan-2-ols (4) have been synthesised by ring opening of various 5, 6-dihydro-6-(4-alkoxyphenyl)-5-(2, 3-epoxypropyl)-3-methyl-s-triazolo[3, 4-b][1, 3, 4]thiadiazoles (3) with mercapto-s-triazoles and evaluated for their effect on blood pressure and heart rate in normotensive anaesthetised rats.

引用

页码：621 / 623

页数：3

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