Antidepressant Treatment with Venlafaxine and Mirtazapine: no Effect on Serum Concentration of Vascular Endothelial Growth Factor (VEGF)

被引：4
|
作者：
Deuschle, M. [1 ]
Gilles, M. [1 ]
Scharnholz, B. [1 ]
Kahl, K. G. [2 ]
机构：
[1] Heidelberg Univ, Fac Med Mannheim, Cent Inst Mental Hlth, Mannheim, Germany
[2] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany
来源：
PHARMACOPSYCHIATRY | 2015年 / 48卷 / 07期
关键词：
vascular endothelial growth factor (VEGF); brain-derived neurotrophic factor (BDNF); depression; remission; antidepressant; NEUROTROPHIC FACTOR; DEPRESSION;
D O I：
10.1055/s-0035-1555849
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Introduction: Depression, stress and antidepressant treatment have been found to modulate the expression of growth factors. Methods: We studied depressed patients receiving randomized treatment with venlafaxine or mirtazapine for 28 days. Results: There was no significant difference between baseline VEGF concentrations in depressed patients compared to healthy controls. We found no significant effect of antidepressant treatment on serum VEGF. Discussion: In contrast to serum BDNF, VEGF may not be a suitable biomarker for effects of antidepressant treatment with venlafaxine or mirtazapine.
引用
收藏
页码：292 / 293
页数：2
相关论文
共 50 条
  • [1] Vascular endothelial growth factor (VEGF) serum concentration after kidney transplantation
    Grandtnerova, Barbara
    Laca, Ludovit
    Ivankova, Jela
    Kubisz, Peter
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 : 526 - 526
  • [2] Concentration of vascular endothelial growth factor (VEGF) in the serum of patients with suspected ovarian cancer
    A Obermair
    C Tempfer
    L Hefler
    O Preyer
    A Kaider
    R Zeillinger
    S Leodolter
    C Kainz
    [J]. British Journal of Cancer, 1998, 77 : 1870 - 1874
  • [3] Concentration of vascular endothelial growth factor (VEGF) in the serum of patients with suspected ovarian cancer
    Obermair, A
    Tempfer, C
    Hefler, L
    Preyer, O
    Kaider, A
    Zeillinger, R
    Leodolter, S
    Kainz, C
    [J]. BRITISH JOURNAL OF CANCER, 1998, 77 (11) : 1870 - 1874
  • [4] Concentration of vascular endothelial growth factor (VEGF) in the serum of patients with malignant bone tumors
    Holzer, G
    Obermair, A
    Koschat, M
    Preyer, O
    Kotz, R
    Trieb, K
    [J]. MEDICAL AND PEDIATRIC ONCOLOGY, 2001, 36 (06): : 601 - 604
  • [5] Association of vascular endothelial growth factor (VEGF) gene polymorphism and increased serum VEGF concentration with pancreatic adenocarcinoma
    Sivaprasad, Siddapuram
    Govardhan, Bale
    Harithakrishna, Ramanujam
    Rao, Guduru Venkat
    Pradeep, Rebala
    Kunal, Bharadhwaj
    Ramakrishna, Nalla
    Anuradha, Shekaran
    Reddy, Duvvuru Nageshwar
    [J]. PANCREATOLOGY, 2013, 13 (03) : 267 - 272
  • [6] Vascular Endothelial Growth Factor (VEGF) serum concentration during electroconvulsive therapy (ECT) in treatment resistant depressed patients
    Minelli, Alessandra
    Zanardini, Roberta
    Abate, Maria
    Bortolomasi, Marco
    Gennarelli, Massimo
    Bocchio-Chiavetto, Luisella
    [J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2011, 35 (05): : 1322 - 1325
  • [7] Vascular endothelial growth factor (VEGF) genotype and serum concentration in Polish patients with basal cell carcinoma
    Sobjanek, Michal
    Zablotna, Monika
    Kozicka, Dorota
    Michajlowski, Igor
    Nedoszytko, Boguslaw
    Wlodarkiewicz, Adam
    Roszkiewicz, Jadwiga
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 : S25 - S25
  • [8] VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) GENOTYPE AND SERUM CONCENTRATION IN PATIENTS WITH PANCREATIC ADENOCARCINOMA AND CHRONIC PANCREATITIS
    Talar-Wojnarowska, R.
    Gasiorowska, A.
    Olakowski, M.
    Lekstan, A.
    Lampe, P.
    Smolarz, B.
    Romanowicz-Makowska, H.
    Kulig, A.
    Malecka-Panas, E.
    [J]. JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2010, 61 (06): : 711 - 716
  • [9] Levels of vascular endothelial growth factor (VEGF) in serum of patients with endometriosis
    Gagné, D
    Pagé, M
    Robitaille, G
    Hugo, P
    Gosselin, D
    [J]. HUMAN REPRODUCTION, 2003, 18 (08) : 1674 - 1680
  • [10] Preoperative serum vascular endothelial growth factor (VEGF) in ovarian masses
    Tanir, HM
    Ozalp, S
    Yalcin, OT
    Colak, O
    Akcay, A
    Senses, T
    [J]. EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2003, 24 (3-4) : 271 - 274
12345