Is glutamine depletion needed in ALL disease?

被引：8
|
作者：
Avramis, Vassilios I. [1 ,2 ]
机构：
[1] Keck Sch Med, Los Angeles, CA 90033 USA
[2] Childrens Hosp Los Angeles, Los Angeles, CA USA
来源：
BLOOD | 2014年 / 123卷 / 23期
关键词：
L-ASPARAGINASE; LEUKEMIA; RESISTANCE;
D O I：
10.1182/blood-2014-04-565523
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Chan et al report on an innovative study using molecular dynamics and mapping to identify and produce a promising bioengineered clone of Escherichia coli asparaginase (ASNase), mutated at Q59L position (Gln59Leu). The Q59L variant ASNase has undetectable glutaminase coactivity, while retaining its ASNase activity © 2014 by The American Society of Hematology.
引用
下载
收藏
页码：3532 / 3533
页数：2
相关论文
共 50 条
  • [1] Glutamine for childhood malnutrition: Is it needed?
    Lima, AAM
    Guerrant, RL
    JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2005, 40 (04): : 526 - 527
  • [2] Glutamine for childhood malnutrition: Probably not needed
    Sondheimer, JM
    JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2005, 40 (01): : 24 - 25
  • [3] Role of glutamine depletion in severe illness
    Darmaun, D
    DIABETES NUTRITION & METABOLISM, 2000, 13 (01) : 25 - 30
  • [4] Vitamin D supplementation in renal disease: Is calcitriol all that is needed?
    Fukagawa, Masafumi
    Komaba, Hirotaka
    Hamano, Takayuki
    SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2012, 72 : 120 - 123
  • [5] Epigenetic silencing of glutamine synthetase (Glul) defines glutamine depletion therapy
    Cavicchioli, F.
    Shia, A.
    O'Leary, K.
    Haley, V.
    Crook, T. R.
    Thompson, A. M.
    Lackner, M.
    Lo, Nigro C.
    Schmid, P.
    CANCER RESEARCH, 2012, 72
  • [6] Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease
    Morris, Claudia R.
    Suh, Jung H.
    Hagar, Ward
    Larkin, Sandra
    Bland, D. Anton
    Steinberg, Martin H.
    Vichinsky, Elliott P.
    Shigenaga, Mark
    Ames, Bruce
    Kuypers, Frans A.
    Klings, Elizabeth S.
    BLOOD, 2008, 111 (01) : 402 - 410
  • [7] Compassion Needed for All
    Waldrop, Julee B.
    JNP-JOURNAL FOR NURSE PRACTITIONERS, 2020, 16 (06): : A8 - A8
  • [8] All of Us Are Needed
    Barnett, Beatrice
    AMERICAN JOURNAL OF NURSING, 1950, 50 (01) : A6 - +
  • [9] All hands needed
    Wilkinson, JE
    JOURNAL OF FORESTRY, 1999, 97 (06) : 61 - 61
  • [10] Enzymatic depletion of circulating glutamine is immunosuppressive in cancers
    Kumar, Monish
    Leekha, Ankita
    Nandy, Suman
    Kulkarni, Rohan
    Martinez-Paniagua, Melisa
    Sefat, K. M. Samiur Rahman
    Willson, Richard C.
    Varadarajan, Navin
    ISCIENCE, 2024, 27 (06)
12345