Anti-SU Antibody Responses in Client-Owned Cats Following Vaccination against Feline Leukaemia Virus with Two Inactivated Whole-Virus Vaccines (Fel-O-Vax(R) Lv-K and Fel-O-Vax(R) 5)

被引：4

作者：

Westman, Mark ^{[1
]}

Norris, Jacqueline ^{[1
]}

Malik, Richard ^{[2
]}

Hofmann-Lehmann, Regina ^{[3
,4
]}

Parr, Yasmin A. ^{[5
]}

Armstrong, Emma ^{[5
]}

McDonald, Mike ^{[6
]}

Hall, Evelyn ^{[1
]}

Sheehy, Paul ^{[1
]}

Hosie, Margaret J. ^{[5
]}

机构：

[1] Univ Sydney, Sydney Sch Vet Sci, Camperdown, NSW 2006, Australia

[2] Univ Sydney, Ctr Vet Educ, Camperdown, NSW 2006, Australia

[3] Univ Zurich, Vetsuisse Fac, Clin Lab, Dept Clin Diagnost & Serv, CH-8057 Zurich, Switzerland

[4] Univ Zurich, Vetsuisse Fac, Ctr Clin Studies, CH-8057 Zurich, Switzerland

[5] MRC Univ Glasgow, Ctr Virus Res, Garscube Campus,Bearsden Rd, Glasgow G61 1QH, Lanark, Scotland

[6] Univ Glasgow, Vet Diagnost Serv, Glasgow G61 1QH, Lanark, Scotland

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 02期

关键词：

Australia; FeLV vaccination; humoral immunity; FeLV infection; vaccine efficacy; veterinary science;

D O I：

10.3390/v13020240

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A field study undertaken in Australia compared the antibody responses induced in client-owned cats that had been vaccinated using two inactivated whole feline leukaemia virus (FeLV) vaccines, the monovalent vaccine Fel-O-Vax(R) Lv-K and the polyvalent vaccine Fel-O-Vax(R) 5. Serum samples from 428 FeLV-uninfected cats (118 FeLV-vaccinated and 310 FeLV-unvaccinated) were tested for anti-FeLV neutralising antibodies (NAb) using a live virus neutralisation assay to identify 378 FeLV-unexposed (NAb-negative) and 50 FeLV-exposed (NAb-positive; abortive infections) cats, following by anti-surface unit (SU) FeLV-A and FeLV-B antibody ELISA testing. An additional 42 FeLV-infected cats (28 presumptively regressively infected, 14 presumptively progressively infected) were also tested for anti-SU antibodies. NAb-positive cats displayed significantly higher anti-SU antibody ELISA responses compared to NAb-negative cats (p < 0.001). FeLV-unexposed cats (NAb-negative) that had been vaccinated less than 18 months after a previous FeLV vaccination using the monovalent vaccine (Fel-O-Vax(R) Lv-K) displayed higher anti-SU antibody ELISA responses than a comparable group vaccinated with the polyvalent vaccine (Fel-O-Vax(R) 5) (p < 0.001 for both anti-FeLV-A and FeLV-B SU antibody responses). This difference in anti-SU antibody responses between cats vaccinated with the monovalent or polyvalent vaccine, however, was not observed in cats that had been naturally exposed to FeLV (NAb-positive) (p = 0.33). It was postulated that vaccination with Fel-O-Vax(R) 5 primed the humoral response prior to FeLV exposure, such that antibody production increased when the animal was challenged, while vaccination with Fel-O-Vax(R) Lv-K induced an immediate preparatory antibody response that did not quantitatively increase after FeLV exposure. These results raise questions about the comparable vaccine efficacy of the different FeLV vaccine formulations and correlates of protection.

引用

页数：18

共 1 条

[1] Antibody Responses in Cats Following Primary and Annual Vaccination against Feline Immunodeficiency Virus (FIV) with an Inactivated Whole-Virus Vaccine (Fel-O-Vax(R) FIV)
Westman, Mark
Yang, Dennis
Green, Jennifer
Norris, Jacqueline
Malik, Richard
Parr, Yasmin A.
McDonald, Mike
Hosie, Margaret J.
VandeWoude, Sue
Miller, Craig
[J]. VIRUSES-BASEL, 2021, 13 (03):

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