Emerging therapeutic targets associated with the immune system in patients with intracerebral haemorrhage (ICH): From mechanisms to translation

被引:53
|
作者
Shao, Anwen [1 ]
Zhu, Zhiyuan [2 ,4 ]
Li, Lingfei [3 ]
Zhang, Shizhong [4 ,5 ]
Zhang, Jianmin [1 ,6 ,7 ]
机构
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurosurg, Hangzhou, Zhejiang, Peoples R China
[2] Univ Hong Kong, Li Ka Shing Fac Med, Div Neurosurg, Dept Surg, Hong Kong, Peoples R China
[3] Zhejiang Univ, Sch Med, Affiliated Hangzhou Peoples Hosp 1, Dept Neurol, Hangzhou, Zhejiang, Peoples R China
[4] Southern Med Univ, Zhujiang Hosp, Dept Neurosurg, 253 Ind Rd, Guangzhou 510282, Guangdong, Peoples R China
[5] Southern Med Univ, Guangdong Prov Key Lab Brain Funct Repair & Regen, Neurosurg Inst Guangdong Prov, Natl Key Clin Specialty, Guangzhou, Guangdong, Peoples R China
[6] Zhejiang Univ, Brain Res Inst, Hangzhou, Zhejiang, Peoples R China
[7] Zhejiang Univ, Collaborat Innovat Ctr Brain Sci, Hangzhou, Zhejiang, Peoples R China
来源
EBIOMEDICINE | 2019年 / 45卷
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
Intracerebral haemorrhage; Secondary brain injury; Immune response; Therapeutic targets; Immunomodulators; ATTENUATES BRAIN EDEMA; NEURAL STEM-CELLS; RECEPTOR; 4; MACROPHAGE ACTIVATION; SUBVENTRICULAR ZONE; CEREBRAL-HEMORRHAGE; FUNCTIONAL RECOVERY; INNATE IMMUNITY; REGULATORY T; INFLAMMATION;
D O I
10.1016/j.ebiom.2019.06.012
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Intracranial haemorrhage (ICH) is a life-threatening type of stroke with high mortality, morbidity, and recurrence rates. However, no effective treatment has been established to improve functional outcomes in patients with ICH to date. Strategies targeting secondary brain injury are of great interest in both experimental and translational studies. The immune system is increasingly considered to be a crucial contributor to ICH-induced brain injury because it participates in multiple phases of ICH, from the early vascular rupture events to brain recovery. Various pathobiological processes that contribute to secondary brain injury closely interact with the immune system, such as brain oedema, neuroinflammation, and neuronal damage. Hence, we summarize the immune response to ICH and recent progress in treatments targeting the immune system in this review. The emerging therapeutic strategies that target the immune system after ICH are a particular focus and have been summarized. (C) 2019 The Authors. Published by Elsevier B.V.
引用
收藏
页码:615 / 623
页数:9
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