Physiological changes induced by salt intake in female Spontaneously Diabetic Torii-Leprfa (SDT fatty) rat, a novel obese type 2 diabetic model

被引：7
|
作者：
Katsuda, Yoshiaki [1 ]
Kemmochi, Yusuke [2 ]
Maki, Mimi [1 ]
Sano, Ryuhei [1 ]
Ishii, Yukihito [1 ]
Miyajima, Katsuhiro [2 ]
Kakimoto, Kochi [2 ]
Ohta, Takeshi [1 ]
机构：
[1] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Takatsuki, Osaka 5691125, Japan
[2] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Toxicol Res Labs, Hadano, Japan
来源：
ANIMAL SCIENCE JOURNAL | 2014年 / 85卷 / 05期
关键词：
blood pressure; salt; SDT fatty rat; BLOOD-PRESSURE; ZUCKER RATS; HYPERTENSION; MELLITUS;
D O I：
10.1111/asj.12191
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Salt plays an important role in the control of blood pressure in obesity and diabetes mellitus. In this study, we investigated physiological changes such as blood pressure and renal function in salt-loaded female Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rats. SDT fatty rats were given 1% NaCl in drinking water for 14 weeks, from 4 to 18 weeks of age. Significant salt-sensitive hypertension was observed in the salt-loaded SDT fatty rats. Moreover, the salt-loaded rats showed a decrease of creatinine clearance and deterioration on pathological renal findings, including glomerulosclerosis and tubular and interstitial lesions. Female SDT fatty rat is a useful model for investigating the mechanisms of high salt sensitivity in obesity and diabetes mellitus.
引用
收藏
页码：588 / 594
页数：7
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  • [1] Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-Leprfa (SDT Fatty) Rats
    Yamaguchi, Takayuki
    Sasase, Tomohiko
    Mera, Yasuko
    Tomimoto, Daisuke
    Tadaki, Hironobu
    Kemmochi, Yusuke
    Ohta, Takeshi
    Sato, Eimei
    Matsushita, Mutsuyoshi
    [J]. JOURNAL OF VETERINARY MEDICAL SCIENCE, 2012, 74 (12): : 1669 - 1673
  • [2] Analysis of haemodynamics and angiogenic response to ischaemia in the obese type 2 diabetic model Spontaneously Diabetic Torii Leprfa (SDT fatty) rats
    Murai, Yasutaka
    Sasase, Tomohiko
    Tadaki, Hironobu
    Heitaku, Shiro
    Imagawa, Naoya
    Yamada, Takahisa
    Ohta, Takeshi
    [J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2020, 47 (04) : 583 - 590
  • [3] Glomerular Hyperfiltration With Hyperglycemia in the Spontaneously Diabetic Torii (SDT) Fatty Rat, an Obese Type 2 Diabetic Model
    Sano, Ryuhei
    Ishii, Yukihito
    Yamanaka, Masao
    Yasui, Yuzo
    Kemmochi, Yusuke
    Kuroki, Fuko
    Sugimoto, Miki
    Fukuda, Sumiaki
    Sasase, Tomohiko
    Miyajima, Katsuhiro
    Nakae, Dai
    Ohta, Takeshi
    [J]. PHYSIOLOGICAL RESEARCH, 2021, 70 (01) : 45 - 54
  • [4] Metabolic Disorders and Diabetic Complications in Spontaneously Diabetic Torii Leprfa Rat: A New Obese Type 2 Diabetic Model
    Kemmochi, Yusuke
    Fukui, Kenji
    Maki, Mimi
    Kimura, Shuichi
    Ishii, Yukihito
    Sasase, Tomohiko
    Miyajima, Katsuhiro
    Ohta, Takeshi
    [J]. JOURNAL OF DIABETES RESEARCH, 2013, 2013
  • [5] Estimation of potential risk of allyl alcohol induced liver injury in diabetic patients using type 2 diabetes spontaneously diabetic Torii-Leprfa (SDT fatty) rats
    Takahashi, Tadakazu
    Matsuura, Chizuru
    Toyoda, Kaoru
    Suzuki, Yusuke
    Yamada, Naohito
    Kobayashi, Akio
    Sugai, Shoichiro
    Shimoi, Kayoko
    [J]. JOURNAL OF TOXICOLOGICAL SCIENCES, 2019, 44 (10-12): : 759 - 776
  • [6] Depression-related behavioural and neuroendocrine changes in the Spontaneously Diabetic Torii (SDT) fatty rat, an animal model of type 2 diabetes mellitus
    Sakimura, Katsuya
    Maekawa, Tatsuya
    Sasagawa, Kazuo
    Ishii, Yukihito
    Kume, Shin-ichi
    Ohta, Takeshi
    [J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2018, 45 (09) : 927 - 933
  • [7] Spontaneously Diabetic Torii (SDT) Fatty Rat, a Novel Animal Model of Type 2 Diabetes Mellitus, Shows Blunted Circadian Rhythms and Melatonin Secretion
    Sakimura, Katsuya
    Maekawa, Tatsuya
    Kume, Shin-ichi
    Ohta, Takeshi
    [J]. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2018, 2018
  • [8] Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model
    Katsuda, Yoshiaki
    Kemmochi, Yusuke
    Maki, Mimi
    Sano, Ryuhei
    Toriniwa, Yasufumi
    Ishii, Yukihito
    Miyajima, Katsuhiro
    Kakimoto, Kochi
    Ohta, Takeshi
    [J]. JOURNAL OF DIABETES RESEARCH, 2014, 2014
  • [9] Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model
    Toriniwa, Yasufumi
    Saito, Tomoyuki
    Miyajima, Katsuhiro
    Ishii, Yukihito
    Uno, Kinuko
    Maekawa, Tatsuya
    Matsui, Tohru
    Kume, Shinichi
    Yamada, Takahisa
    Ohta, Takeshi
    [J]. JOURNAL OF VETERINARY MEDICAL SCIENCE, 2018, 80 (06): : 878 - 885
  • [10] A novel model of obesity-related diabetes:: Introgression of the Leptfa allele of the Zucker fatty rat into nonobese Spontaneously Diabetic Torii (SDT) rats
    Masuyama, T
    Katsuda, Y
    Shinohara, M
    [J]. EXPERIMENTAL ANIMALS, 2005, 54 (01) : 13 - 20
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