Synaptic Receptor Diversity Revealed Across Space and Time

被引:7
|
作者
Swanger, Sharon A. [1 ,2 ]
Traynelis, Stephen F. [3 ]
机构
[1] Virginia Tech Caril Res Inst, Roanoke, VA USA
[2] Virginia Tech, Virginia Maryland Coll Vet Med, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24016 USA
[3] Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 USA
关键词
HETEROMERIC NMDA RECEPTORS; MOLECULAR-CLONING; VISUAL-CORTEX; CHANNEL; CURRENTS;
D O I
10.1016/j.tins.2018.06.001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In their 1994 paper, Monyer et al. described unique functional properties and cell type-specific expression of NMDA receptor (NMDAR) GluN2 subunits, suggesting that the roles of NMDAR vary across brain regions and throughout development. This influential work not only provided insight into how molecular diversity impacts synapse function, but also continues to inform new approaches for modulating brain circuits.
引用
收藏
页码:486 / 488
页数:4
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