M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge

被引：13

作者：

Srour, Nivine ^{[1
,2
,3
]}

Mersaoui, Sofiane Y. ^{[1
,2
,3
]}

Richard, Stephane ^{[1
,2
,3
]}

机构：

[1] McGill Univ, Segal Canc Ctr, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

[2] McGill Univ, Dept Oncol, Montreal, PQ H3T 1E2, Canada

[3] McGill Univ, Dept Med, Montreal, PQ H3T 1E2, Canada

来源：

CANCER CELL | 2019年 / 36卷 / 01期

基金：

加拿大健康研究院;

关键词：

INHIBITOR;

D O I：

10.1016/j.ccell.2019.06.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, Fedoriw and colleagues characterize a potent reversible inhibitor of type I PRMTs, GSK3368715, with anti-proliferative effects on numerous cancer types. Using a combination of GSK3368715 with PRMT5 inhibitors, the authors show that a threshold of overall arginine methylation reduction needs to be achieved for synergistic anti-tumor activity.

引用

页码：3 / 5

页数：4

共 15 条

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Mann, Sarah A.
Salsburg, Andrew
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BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 27 (01) : 224 - 229
[2] Role of PRMT1 and PRMT5 in Breast Cancer
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[3] PRMT1 loss sensitizes cells to PRMT5 inhibition
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NUCLEIC ACIDS RESEARCH, 2019, 47 (10) : 5038 - 5048
[4] The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells
Mingyue Li
Wentao An
Linyan Xu
Yidan Lin
Ling Su
Xiangguo Liu
Journal of Experimental & Clinical Cancer Research, 38
[5] The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells
Li, Mingyue
An, Wentao
Xu, Linyan
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JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 38 (1)
[6] Pan-cancer analysis identifies protein arginine methyltransferases PRMT1 and PRMT5 and their related signatures as markers associated with prognosis, immune profile, and therapeutic response in lung adenocarcinoma
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Wu, Meng
Sun, Jujie
Chen, Minxin
Zhang, Zengfu
Yu, Jinming
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HELIYON, 2023, 9 (12)
[7] Dysregulated YY1/PRMT5 axis promotes the progression and metastasis of laryngeal cancer by targeting Hippo pathway
Wang, Nan
Wu, Di
Long, Qian
Yan, Yue
Chen, Xiaoqi
Zhao, Zheng
Yan, Honghong
Zhang, Xinrui
Xu, Meilan
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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2021, 25 (02) : 946 - 959
[8] MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
Marjon, Katya
Cameron, Michael J.
Quang, Phong
Clasquin, Michelle F.
Mandley, Everton
Kunii, Kaiko
Mcvay, Michael
Choe, Sung
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Konteatis, Zenon
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CELL REPORTS, 2016, 15 (03): : 574 - 587
[9] Arginine methyltransferase inhibitor 1 inhibits gastric cancer by downregulating eIF4E and targeting PRMT5
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TOXICOLOGY AND APPLIED PHARMACOLOGY, 2017, 336 : 1 - 7
[10] Exosomal circRNA RHOT1 promotes breast cancer progression by targeting miR-204-5p/PRMT5 axis
Jiang, Weihua
Yu, Yinping
Ou, Jianghua
Li, Yongtao
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CANCER CELL INTERNATIONAL, 2023, 23 (01)

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