Gut microbiota associations with common diseases and prescription medications in a population-based cohort

被引：334
|
作者：
Jackson, Matthew A. [1 ,2 ]
Verdi, Serena [1 ]
Maxan, Maria-Emanuela [3 ]
Shin, Cheol Min [1 ,4 ]
Zierer, Jonas [1 ,5 ]
Bowyer, Ruth C. E. [1 ]
Martin, Tiphaine [1 ,6 ]
Williams, Frances M. K. [1 ]
Menni, Cristina [1 ]
Bell, Jordana T. [1 ]
Spector, Tim D. [1 ]
Steves, Claire J. [1 ,3 ]
机构：
[1] Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
[2] Univ Oxford, Kennedy Inst Rheumatol, Oxford OX3 7FY, England
[3] Kings Coll Hosp Fdn Trust, Clin Age Res Unit, London SE5 9RS, England
[4] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, Gyeonggi Do, South Korea
[5] Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, D-85764 Neuherberg, Germany
[6] Icahn Sch Med Mt Sinai, Tisch Inst Canc, Dept Oncol Sci, New York, NY 10029 USA
来源：
NATURE COMMUNICATIONS | 2018年 / 9卷
基金：
美国国家卫生研究院; 英国惠康基金;
关键词：
GENETICS;
D O I：
10.1038/s41467-018-05184-7
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut microbiota profiles are available for >2700 members of the deeply phenotyped TwinsUK cohort, providing a uniform platform for such comparisons. Here, we present gut microbiota association analyses for 38 common diseases and 51 medications within the cohort. We describe several novel associations, highlight associations common across multiple diseases, and determine which diseases and medications have the greatest association with the gut microbiota. These results provide a reference for future studies of the gut microbiome and its role in human health.
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页数：8
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