Albumin-to-globulin ratio as an independent predictor of mortality in chronic heart failure

被引：30
|
作者：
Niedziela, Jacek T. [1 ]
Hudzik, Bartosz [1 ,2 ]
Szygula-Jurkiewicz, Bozena [1 ]
Nowak, Jolanta U. [1 ]
Polonski, Lech [1 ]
Gasior, Mariusz [1 ]
Rozentryt, Piotr [1 ,3 ]
机构：
[1] Med Univ Silesia, Silesian Ctr Heart Dis, Sch Med, Div Dent Zabrze,Dept Cardiol 3, Zabrze, Poland
[2] Med Univ Silesia, Sch Publ Hlth Bytom, Dept Nutr Related Dis Prevent, Katowice, Poland
[3] Med Univ Silesia, Sch Publ Hlth Bytom, Dept Social Med & Prevent, Katowice, Poland
来源：
BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 07期
关键词：
albumin-to-globulin ratio; biomarkers; cardiovascular disease; heart failure; prognosis; COLLOID OSMOTIC-PRESSURE; PRETREATMENT ALBUMIN; PREOPERATIVE ALBUMIN; SERUM; HYPOALBUMINEMIA; PROTEINS; CACHEXIA;
D O I：
10.2217/bmm-2017-0378
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: Albumin-to-globulin ratio (AGR) is emerged as a marker of impaired prognosis. We determined the predictive value of AGR in patients with heart failure with reduced ejection fraction (HFrEF). Methodology: 999 patients with HFrEF were enrolled. Rates of 1-year all-cause mortality were compared between AGR quartiles (Q). Moreover, multivariate survival analysis in Cox's regression model and receiver operating characteristic analyses were performed. Results: 90-day and 1-year mortality was the highest in AGR Q1. AGR was an independent predictor of 90-day and 1-year mortality. Receiver operating characteristic analysis revealed moderate diagnostic value in predicting 90-day (AGR cutoff < 1.2) and 1-year (AGR cutoff < 1.38) mortality. Conclusion: AGR had a good prognostic value and remained an independent predictor of mortality in HFrEF patients.
引用
收藏
页码：749 / 757
页数：9
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