Common biological mechanisms between bipolar disorder and type 2 diabetes: Focus on inflammation

被引:31
|
作者
Sharma, Ajaykumar N. [1 ,2 ,3 ]
Bauer, Isabelle E. [1 ]
Sanches, Marsal [1 ]
Galvez, Juan F. [1 ]
Zunta-Soares, Giovana B. [1 ]
Quevedo, Joao [2 ,4 ]
Kapczinski, Flavio [3 ,5 ]
Soares, Jair C. [1 ]
机构
[1] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, UT Ctr Excellence Mood Disorders, Houston, TX 77030 USA
[2] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Ctr Expt Models Psychiat, Houston, TX 77030 USA
[3] Univ Texas Med Sch Houston, Dept Psychiat & Behav Sci, Ctr Mol Psychiat, Houston, TX USA
[4] Univ Southern Santa Catarina, Hlth Sci Unit, Grad Program Hlth Sci, Neurosci Lab, Criciuma, SC, Brazil
[5] Univ Fed Rio Grande do Sul, Dept Psychiat & Legal Med, Lab Mol Psychiat, Porto Alegre, RS, Brazil
基金
美国国家卫生研究院;
关键词
Biomarker; Bipolar disorder; Comorbidity; Inflammation; Type; 2; diabetes; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; INTERLEUKIN-1 RECEPTOR ANTAGONIST; GLYCATION END-PRODUCTS; RANDOMIZED CONTROLLED-TRIAL; SERUM LITHIUM LEVELS; BODY-MASS INDEX; NF-KAPPA-B; INSULIN-RESISTANCE; METABOLIC SYNDROME;
D O I
10.1016/j.pnpbp.2014.06.005
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: Bipolar disorder (BD) patients present a 3-5 fold greater risk of developing type 2 diabetes (T2D) compared to general population. The underlying mechanisms for the increased prevalence of T2D in BD population are poorly understood. Objectives: The purpose of this review is to critically review evidence suggesting that inflammation may have an important role in the development of both BD and T2D. Results: The literature covered in this review suggests that inflammatory dysregulation take place among many BD patients. Such dysregulated and low grade chronic inflammatory process may also increase the prevalence of T2D in BD population. Current evidence supports the hypothesis of dysregulated inflammatory processes as a critical upstream event in BD as well as in T2D. Conclusions: Inflammation may be a factor for the development of T2D in BD population. The identification of inflammatory markers common to these two medical conditions will enable researchers and clinicians to better understand the etiology of BD and develop treatments that simultaneously target all aspects of this multi-system condition. (C) 2014 Published by Elsevier Inc.
引用
收藏
页码:289 / 298
页数:10
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