Synthesis and Antioxidant Activity of Novel Quinazolinones Functionalized with Urea/Thiourea/Thiazole Derivatives as 5-Lipoxygenase Inhibitors

被引：28

作者：

Prashanth, Maralekere K. ^{[1
]}

Revanasiddappa, Hosakere D. ^{[1
]}

机构：

[1] Univ Mysore, Dept Chem, Manasagangothri Mysore 570006, Karnataka, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2014年 / 11卷 / 06期

关键词：

Quinazolinone; Thiazole; Thiourea; Antioxidant; 5-LOX; MEDIATED TOTAL-SYNTHESIS; CARBAZOMYCIN-B; ANTIINFLAMMATORY AGENTS; ORGANIC-SYNTHESIS; COMPLEXES; ANTIBACTERIAL; ANALOGS; ACID;

D O I：

10.2174/1570180811666131230235157

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present study, a series of novel quinazolinones functionalized with urea/ thiourea/ thiazole derivatives was synthesized and evaluated for their antioxidant and 5-lipoxygenase (5-LOX) inhibition activities. The newly synthesized compounds were characterized using H-1 NMR, C-13 NMR, IR, Mass spectra and elemental analysis. The antioxidant activities of the title compounds were evaluated using DPPH, superoxide, hydroxyl and nitric oxide radical scavenging assay in vitro. It is revealed from the antioxidant screening results that the compounds 3e, 5f and 6c manifested profound antioxidant potential. The synthesized compounds were screened for their 5-LOX inhibitory activity. Overall, 3e, 5f and 6c showed promising antioxidant and 5f showed 5-LOX inhibitory activity and may be used as the lead compounds in the future study.

引用

页码：712 / 720

页数：9

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