Role of adenylate cyclase-associated protein 1 in cancers

被引：0
|
作者：
Xie, Shuanshuan [1 ]
Shen, Changxing [1 ]
Zhou, Shunping [1 ,2 ]
Xiong, Mengting [1 ]
Tan, Min [1 ]
Song, Xiaolian [1 ]
Wang, Changhui [1 ]
机构：
[1] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Resp Med, Shanghai 200072, Peoples R China
[2] Tongji Univ, Sch Med, Yangpu Hosp, Dept Cardiol Med, Shanghai 200090, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2018年 / 11卷 / 04期
基金：
中国国家自然科学基金;
关键词：
CAP1; cancer; overall survival; actin cytoskeleton; GENE-EXPRESSION PROFILES; CELL CARCINOMA; MICROARRAY DATA; OVARIAN-CANCER; CAP; ADENOCARCINOMA; METASTASIS; PATTERNS; IDENTIFICATION; CHEMOTHERAPY;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cancer is a leading cause of death worldwide. Adenylate cyclase-associated protein 1 (CAP1) may play a role in cell motility and in the development of certain types of cancer. Here, we explore the expression of CAP1 in primary tumor tissues using the Oncomine database for four cancers with the highest mortality. In addition, we studied the correlation between CAP1 expression and overall survival using Kaplan-Meier analysis. We analyzed the structure and function of CAP1 in cancers. We found widespread upregulation of the expression of CAP1 gene in primary tumor tissues. There was also a correlation between CAP1 expression levels and patient survival. These data provide additional evidence for CAP1 as a biomarker for cancer studies and as a target for cancer diagnose.
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页码：3086 / 3099
页数：14
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