Cerium Oxide Nanoparticles and Its Cytotoxicity Human Lung Cancer Cells

被引：0

作者：

Diaconeasa, Zorita ^{[1
]}

Barbu-Tudoran, Lucian ^{[2
]}

Coman, Cristina ^{[1
]}

Leopold, Loredana ^{[1
]}

Mesaros, Amalia ^{[3
]}

Pop, Oana ^{[1
]}

Rugina, Dumitrita ^{[4
]}

Stefan, Razvan ^{[4
]}

Tabaran, Flaviu ^{[4
]}

Tripon, Septimiu ^{[2
]}

Socaciu, Carmen ^{[1
]}

机构：

[1] Univ Agr Sci & Vet Med Cluj Napoca, Fac Food Sci & Technol, Cluj Napoca 400372, Romania

[2] Univ Babes Bolyai, Fac Biol & Geol, Cluj Napoca 400006, Romania

[3] Tech Univ, Fac Mat Engn & Environm, Cluj Napoca 400641, Romania

[4] Univ Agr Sci & Vet Med Cluj Napoca, Fac Vet Med, Cluj Napoca 400372, Romania

来源：

ROMANIAN BIOTECHNOLOGICAL LETTERS | 2015年 / 20卷 / 04期

关键词：

cerium oxide nanoparticles; lung cancer; microscopy; Draq; 5; ADJUVANT CHEMOTHERAPY; CONDUCTIVITY; ANTIOXIDANT; NANOCERIA; SURVIVAL; PROTECT;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Owing to their radical scavenging nanoparticles (CeO2-NPs) are currently used for various applications, including drug delivery or alternative chemotherapy agents. In this paper, the cellular uptake and cytotoxicity caused by small size CeO2-NPs (20-nm) on cultured human lung cancer cells was evaluated. The MTT assay was used to assess cell viability after 24h exposure to 0 to 250 mu g/ml of CeO2-NPs. The results showed a dose dependent and exposure time decreased of cell viability. Cellular uptake was confirmed by the conjugation of CeO2-NPs with a fluorescent dye rhodamine-6G using confocal microscopy.

引用

页码：10679 / 10687

页数：9

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