Probing protein-carbohydrate interactions with microarrays of synthetic oligosaccharides

被引：155
|
作者：
Ratner, DM
Adams, EW
Su, J
O'Keefe, BR
Mrksich, M
Seeberger, PH
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
[2] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
[3] Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA
[4] NCI, Mol Targets Discovery Program, Ctr Canc Res, Frederick, MD 21702 USA
来源：
CHEMBIOCHEM | 2004年 / 5卷 / 03期
关键词：
carbohydrate chips; carbohydrates; lectins; microarrays; proteins;
D O I：
10.1002/cbic.200300804
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
On the spot: Carbohydrate microarrays, in concert with surface plasmon resonance, are valuable tools in the rapid identification of carbohydrate - protein interactions, like those between high-mannose oligosaccharides and cyanovirin-N (see picture). By utilizing chemical methods amenable to current high-throughput screening technologies, high-density carbohydrate micro-arrays can be prepared and screened by using conventional and widely accessible DNA microarray screening instrumentation.
引用
收藏
页码：379 / 382
页数：4
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