Synthesis of (R)-1,3-butanediol by enantioselective oxidation using whole recombinant Escherichia coli cells expressing (S)-specific secondary alcohol dehydrogenase

被引：26
|
作者：
Yamamoto, H [1 ]
Matsuyama, A [1 ]
Kobayashi, Y [1 ]
机构：
[1] Daicel Chem Ind Ltd, Tsukuba Res Ctr, Tsukuba, Ibaraki 3050841, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2002年 / 66卷 / 04期
关键词：
secondary alcohol dehydrogenase; (R)-1,3-butanediol; NAD(+)-regeneration; enantioselective oxidation;
D O I：
10.1271/bbb.66.925
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of (R)-1,3-butanediol (BDO) from its racemate was studied using whole cells of recombinant Escherichia coli expressing an (S)-specific secondary alcohol dehydrogenase (CpSADH) from Candida parapsilosis by enantioselective oxidation. Under the optimized conditions, the yield of (R)-1,3-BDO reached 72.6 g/l, with a molar recovery yield of 48.4% from a racemate of 15% and an optical purity of 95% ee.
引用
收藏
页码：925 / 927
页数：3
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