This research was aimed to investigate the clinical efficacy of Ligasure vessel sealing system combined with total abdominal hysterectomy in the treatment of cervical carcinoma. Ninety-six patients with cervical carcinoma admitted to the Department of Gynaecology and Obstetrics of our hospital between October 2013 and October 2015 were selected. All patients received total abdominal hysterectomy. Using a number table, all patients were randomly divided into L group (Ligasure technology) and C group (conventional technology) equally. Intraoperatively, the L group was treated with Ligasure vessel sealing system while the C group with conventional suture system. Duration of surgery, intraoperative blood loss, postoperative drainage volume, visual analogue scale (VAS) score for postoperative pain, exhaust time of the digestive system, length of hospital stay, postoperative complications and clinical efficacy were observed. Duration of surgery, intraoperative blood loss, postoperative drainage volume, exhaust time of the digestive system and length of hospital stay in the L group were all significantly less than the C group (P<0.05). The number of intraoperatively dissected lymph nodes of the two groups showed no significant difference (P>0.05). Comparison of postoperative VAS score revealed that VAS score 1 and 3 days after surgery in the L group was evidently lower than the C group (P<0.05), and no significant differences in VAS score 5 and 7 days after surgery between the two groups (P>0.05). Compared with the C group, the incidence of postoperative complications in the L group was significantly lower (P<0.05). As for postoperative clinical efficiency, the L group was obviously superior to the C group (P<0.05). Ligasure vessel sealing system combined with total abdominal hysterectomy in the treatment of cervical carcinoma is characterized by a significant effect, high safety and effectively reduces postoperative complications. Therefore, it is suitable for wide clinical application.