Impact of TNF Haplotypes in the Physical Course of Acne Vulgaris

被引：17

作者：

Grech, Loanna ^{[1
]}

Giatrakos, Sophia ^{[2
]}

Damoraki, Georgia ^{[3
]}

Kaldrimidis, Philippos ^{[4
]}

Rigopoulos, Dimitrios ^{[2
]}

Gianlarellos-Bourboulis, Evangelos J. ^{[3
]}

机构：

[1] Univ Athens, Sch Med, Dept Aesthet & Cosmetol, Sch Profess Hlth & Welf,Technol Educ Inst Athens, GR-11527 Athens, Greece

[2] Univ Athens, Sch Med, Dept Dermatol & Venereol 2, GR-11527 Athens, Greece

[3] Attikon Univ Hosp, Dept Internal Med 4, GR-12462 Athens, Greece

[4] Metaxas Mem Anticancer Hosp, Dept Endocrinol, Piraeus, Greece

来源：

DERMATOLOGY | 2014年 / 228卷 / 02期

关键词：

Acne vulgaris; Acne conglobata; TNF haplotypes; SINGLE NUCLEOTIDE POLYMORPHISMS; FACTOR-ALPHA GENE; ASSOCIATION; PROMOTER; SUSCEPTIBILITY; EPIDEMIOLOGY; WOMEN;

D O I：

10.1159/000356388

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: The role of single-nucleotide polymorphisms (SNPs) of the TNF gene in acne vulgaris remains controversial. Methods: Genomic DNA was isolated from 185 patients with acne vulgaris and 165 healthy controls. SNPs at positions 376, 308 and 238 of the promoter region of TNF were defined. Results: The frequency of the GAG haplotype was greater among patients (16.8%) than among controls with borderline significance (9.7%, p = 0.059). Male carriers of haplotypes other than GGG presented acne vulgaris at a later age than carriers of the GGG haplotype. No effect of the GAG haplotype on the frequency of acne conglobata was found among women with polycystic ovary syndrome. Conclusions: Carriage of the GAG haplotype of TNF is linked with borderline susceptibility to acne vulgaris. The GGG haplotype is related with earlier disease onset in male patients. (C) 2013 S. Karger AG, Basel

引用

页码：152 / 157

页数：6

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