Structural determination of mannopeptimycin cyclic acetals

被引：8
|
作者：
He, HY [1 ]
Wang, TZ
Dushin, RG
Feng, XD
Shen, B
Ashcroft, JS
Koehn, FE
Carter, GT
机构：
[1] Dept Struct & Nat Prod Chem Chem & Screening Sci, Pearl River, NY 10965 USA
[2] Dept Med Chem Chem & Screening Sci, Pearl River, NY 10965 USA
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 30期
关键词：
D O I：
10.1016/j.tetlet.2004.05.155
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In structure-activity relationship (SAR) studies on mannopeptimycin antibiotics, mannopeptimycin of alpha(1) was acetalized by reacting with certain dialkyl acetals under acidic conditions. The major products of these reactions were determined to be cyclic acetals at the 4,6-positions of the terminal mannose (Man-B), by exemplary spectroscopic analyses of two typical acetalization products 2 and 3. (C) 2004 Published by Elsevier Ltd.
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页码：5889 / 5893
页数：5
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