HPLC method for the analysis of paracetamol, caffeine and dipyrone

被引：0
|
作者：
Altun, ML [1 ]
机构：
[1] Ankara Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey
来源：
TURKISH JOURNAL OF CHEMISTRY | 2002年 / 26卷 / 04期
关键词：
paracetamol; acetaminophen; caffeine; dipyrone; high performance liquid chromatography; validation;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An accurate. simple, reproducible and sensitive method for the determination of paracetamol. caffeine and dipyrone was developed and validated. Paracetamol, caffeine and dipyrone were separated using a mu-Bondapack C-8 column by isocratic elution with a flow rate of 1.0 ml/min. The mobile phase composition was 0.01 M KH2 PO4-methanol-acetonitrile-isopropyl alcohol (420: 20 30: 30) and spectrophotometric detection was carried out at 215 nm. The linear range of determination for paracetamol, caffeine and dipyrone were 0.409-400 mug/ml, 0.151-200 mug/ml and 0.233-600 mug/ml. respectively. The method was shown to be linear, reproducible, specific, sensitive and rugged.
引用
收藏
页码：521 / 528
页数：8
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