Microwave-Assisted, One-Pot Synthesis of 5-Thia-4b,10-diaza-indeno[2,1-a]-indene-5,5-dioxide and 10H-11-Thia-5,10a-diaza-benzo[b]fluorene-11,11-dioxide

被引：1

作者：

Cole, Andrew G. ^{[1
]}

Kultgen, Steven G. ^{[1
]}

Henderson, Ian ^{[1
]}

机构：

[1] Ligand Pharmaceut Inc, Dept Chem, Cranbury, NJ 08512 USA

来源：

SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 20期

关键词：

Microwave-assisted organic synthesis; one-pot; tetracycle; BATRACYLIN NSC-320846; DERIVATIVES;

D O I：

10.1080/00397910902788182

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The one-pot, microwave-assisted synthesis of 5-thia-4b,10-diaza-indeno[2,1-a]indene-5,5-dioxide (6) and 10H-11-thia-5,10a-diaza-benzo[b]fluorene-11,11-dioxide (7) from 1,2-phenylenediamine and 2-aminobenzylamine, respectively, is described. Generation of a sulfonamide through reaction of the appropriate diamine with 2-cyanobenzenesulfonyl chloride is followed by a multistep intramolecular transformation and subsequent elimination of ammonia to provide the corresponding tetracycle in good yield.

引用

页码：3607 / 3610

页数：4