Expression of PACAP receptors in the frog brain during development

被引:1
|
作者
Ciarlo, Monica
Bruzzone, Federica
Angelini, Cristiano
Alexandre, David
Anouar, Youssef
Vallarino, Mauro
Vaudry, Hubert
机构
[1] Univ Genoa, Dept Biol, I-16132 Genoa, Italy
[2] Univ Rouen, European Inst Peptide Res, IFRMP23, Lab Cellular & Mol Neuroendocrinol,INSERM U413, F-76821 Mont St Aignan, France
来源
VIP, PACAP, AND RELATED PEPTIDES: FROM GENE TO THERAPY | 2006年 / 1070卷
关键词
receptors; PACAP; VIP; ontogeny; frog brain; whole mount in situ hybridization;
D O I
10.1196/annals.1317.014
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This study describes the expression of PAC1 and VPAC1 receptor (PAC1-R and VPAC1-R) mRNAs in the brain of frog (Rana esculenta) during development. PAC1-R mRNA was detected in the periventricular and subependymal layers of the thalamus and epithalamus and in the ependymal layer of the mesencephalon and rhombencephalon (stage 20), in the amygdala, in the habenular complex, in the periventricular nucleus of the hypothalamus, and in the ventral cerebellum (stage 30). VPAC1-R mRNA expression was observed only at stage 20, in the floor of the hypothalamus. These results suggest that, in amphibians, pituitary adenylate cyclase-activating polypeptide (PACAP) may play a role in brain development.
引用
收藏
页码:201 / 204
页数:4
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