Polyglutamine diminishes VEGR: Passage to motor neuron death?

被引：4
|
作者：
Katsuno, M [1 ]
Sobue, G [1 ]
机构：
[1] Nagoya Univ, Grad Sch Med, Dept Neurol, Nagoya, Aichi 4668550, Japan
来源：
NEURON | 2004年 / 41卷 / 05期
关键词：
D O I：
10.1016/S0896-6273(04)00110-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Altered gene transcription has been implicated in the pathogenesis of polyglutamine-dependent neurodegeneration. In this issue of Neuron, Sopher et al. demonstrate that androgen receptors containing expanded polyglutamine cause decreased expression of vascular endothelial growth factor (VEGF) by interfering with cAMP response element binding protein binding protein (CBP), thereby contributing to the motor neuron degeneration in spinal and bulbar muscular atrophy.
引用
收藏
页码：677 / 679
页数：3
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