The efficacy of minidose of pour-on ivermectin and eprinomectin formulations against first instar larvae of Przhevalskiana silenus was observed in naturally infested goats in the Jammu region, North India. The study was performed in mid August 2011. A total of 280 goats were randomly divided in to 7 groups of 40 each. Goats of the first three groups were treated with pour-on ivermectin at dosage of 2, 5, and 200 mu g/kg body weight, respectively, whereas animals of the fourth to sixth groups were treated with pour-on eprinomectin at 25, 50, and 500 mu g/kg body weight, respectively. Group VII animals were kept as untreated control. The results indicated that no warbles were recorded between December 2011 and March 2012 on back of animals treated with pour-on preparations of ivermectin at dosage of 5 and 200 mu g/kg body weight, respectively, and eprinomectin at dosage of 50 and 500 mu g/kg body weight, respectively. Thus, it is concluded that administration of minidose of pour-on ivermectin (5 mu g/kg body weight) and eprinomectin (50 mu g/kg body weight) is cost effective and so can be used for warble fly control campaign in Jammu region.