PFKFB3: A Potential Key to Ocular Angiogenesis

被引：11

作者：

Zhou, Zi-Yi ^{[1
]}

Wang, Lin ^{[2
]}

Wang, Yu-Sheng ^{[1
]}

Dou, Guo-Rui ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Eye Inst Chinese PLA, Xijing Hosp, Dept Ophthalmol, Xian, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Hepatobiliary Surg, Xian, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

基金：

中国国家自然科学基金;

关键词：

ocular angiogenesis; PFKFB3; endothelial metabolism; glycolysis; endothelial cell; ENDOTHELIAL GROWTH-FACTOR; CELL-METABOLISM; MOLECULAR-MECHANISMS; RETINAL VASCULATURE; GLYCOLYTIC FLUX; CANCER-CELLS; FACTOR VEGF; RETINOPATHY; LACTATE; OXYGEN;

D O I：

10.3389/fcell.2021.628317

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The current treatment for ocular pathological angiogenesis mainly focuses on anti-VEGF signals. This treatment has been confirmed as effective despite the unfavorable side effects and unsatisfactory efficiency. Recently, endothelial cell metabolism, especially glycolysis, has been attracting attention as a potential treatment by an increasing number of researchers. Emerging evidence has shown that regulation of endothelial glycolysis can influence vessel sprouting. This new evidence has raised the potential for novel treatment targets that have been overlooked for a long time. In this review, we discuss the process of endothelial glycolysis as a promising target and consider regulation of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as treatment for ocular pathological angiogenesis.

引用

页数：14

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