Hodgkin's Lymphoma: Diagnostic Difficulties in Fine-Needle Aspiration Cytology

被引:35
|
作者
Das, Dilip K. [1 ,2 ]
Francis, Issam M. [1 ,3 ]
Sharma, Prem N. [4 ]
Sathar, Sitara A. [1 ]
John, Bency [1 ]
George, Sara S. [1 ]
Mallik, Mrinmay K. [2 ]
Sheikh, Zaffar A. [2 ]
Haji, Bahiyah E. [2 ]
Pathan, Shahed K. [2 ]
Madda, John P. [5 ]
Mirza, Kahvic [6 ]
Ahmed, Mahamoud S. [7 ]
Junaid, Thamradeen A. [1 ,8 ]
机构
[1] Kuwait Univ, Dept Pathol, Jabriya, Kuwait
[2] Mubarak Al Kabeer Hosp, Dept Cytol, Jabriya, Kuwait
[3] Hussain Makki Al Juma Ctr Specialized Surg, Dept Histopathol, Shuwaikh, Kuwait
[4] Kuwait Univ, Hlth Sci Ctr, Vice Presidents Off, Jabriya, Kuwait
[5] Al Amiri Hosp, Dept Histopathol, Kuwait, Kuwait
[6] Al Jahra Hosp, Dept Histopathol, Jahra, Kuwait
[7] Al Adan Hosp, Dept Histopathol, Fahaheel, Kuwait
[8] Mubarak Al Kabeer Hosp, Dept Histopathol, Jabriya, Kuwait
关键词
Hodgkin's lymphoma; non-Hodgkin's lymphoma; fine needle aspiration cytology; anaplastic large cell lymphoma; T-cell-rich B-cell lymphoma; B-CELL LYMPHOMA; REED-STERNBERG CELLS; MALIGNANT-LYMPHOMA; DISEASE; BIOPSY; IMMUNOCYTOCHEMISTRY; CLASSIFICATION; CYTODIAGNOSIS; DISTINCTION; LIMITATIONS;
D O I
10.1002/dc.21064
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
It is commonly believed that cytodiagnosis of Hodgkin's lymphoma (HL) is much easier than that of non-Hodgkin lymphoma (NHL). However, recognition of certain NHL subtypes with Reed-Sternberg (R-S)-like cells and results of immunohistochemical studies point to the contrary. To study the limitations of cytology in diagnosis of HL, fine-needle aspiration (FNA) smears of 130 lymphoma or suspected lymphoma cases were reviewed. Initial and reviewed cytodiagnoses were compared with histopathology in 89 cases. Immunocytochemical and immunohistochemical studies were performed in 56 and 59 cases, respectively. Among histologically diagnosed HL cases, definitive cytodiagnosis of HL (initial as well as reviewed) was significantly less frequent than cytodiagnosis of NHL among histologically diagnosed NHL cases (P = 0.0328 and = 0.0001, respectively). On the other hand, cytologically diagnosed HL/NHL cases were significantly more frequent in the former group (P = 0.0001 and = 0.0018, respectively). ALCL and TCRBCL were the two NHL subtypes which created confusion with HL in FNA smears. Twenty-one cytohistological concordant HL cases and equal number of discordant cases were compared. When compared with discordant group, the patients in concordant group were significantly younger (P = 0.045). Hodgkin/Hodgkin-like cells and typical R-S cells were significantly more frequent in FNA smears of the concordant group (P = 0.0478 and = 0.0431, respectively). Immunocytochemical and immunohistochemical studies showed good correlation with histological diagnosis of HL. It is suggested that proper interpretation of cytologic features, together with use of immunocytochemical parameters can help in reducing the margin of error in cytodiagnois of HL. Diagn. Cytopathol. 2009;37:564-573. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码:564 / 573
页数:10
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