Panton-Valentine Leukocidin-positive Staphylococcus aureus: a potentially significant pathogen in cystic fibrosis

被引：3
|
作者：
Barry, Peter J. [1 ]
Isalska, Barbara J. [2 ]
Jones, Andrew M. [3 ]
机构：
[1] Univ S Manchester Hosp, Manchester Adult Cyst Fibrosis Ctr, Manchester M23 9LT, Lancs, England
[2] Univ S Manchester Hosp, Dept Microbiol, Manchester M23 9LT, Lancs, England
[3] Univ Manchester, Inst Inflammat & Repair, Manchester M13 9PL, Lancs, England
来源：
PAEDIATRIC RESPIRATORY REVIEWS | 2014年 / 15卷
关键词：
PVL; Cystic fibrosis; Staphylococcus aureus; Pneumonia; Infection control; NECROTIZING PNEUMONIA; TRANSMISSION; PREVALENCE;
D O I：
10.1016/j.prrv.2014.04.008
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Staphylococcus aureus is an important pathogen within the context of cystic fibrosis lung disease. Case reports have identified a strong association between the toxin Panton-Valentine Leukocidin (PVL) and lethal necrotizing pneumonia in healthy immunocompetent patients. PVL+ strains of Staphylococcus aureus have also been identified in patients with cystic fibrosis. We describe a further case of pneumonia in a patient with cystic fibrosis, and outline potential transmission of the organism from healthy family members to this patient. We review the evidence regarding the pathogenicity of PVL toxin with a special reference to patients with cystic fibrosis. We outline current concerns regarding the potential transmission of the organism and possible treatment strategies. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：22 / 25
页数：4
相关论文
共 50 条
  • [1] Transmission of Panton-Valentine leukocidin-positive Staphylococcus aureus between patients with cystic fibrosis
    Elizur, Arnon
    Orscheln, Rachel C.
    Ferkol, Thomas W.
    Dunne, W. Michael, Jr.
    Storch, Gregory A.
    Cannon, Carolyn L.
    [J]. JOURNAL OF PEDIATRICS, 2007, 151 (01): : 90 - 92
  • [2] Panton-Valentine leukocidin-positive Staphylococcus aureus, Singapore
    Hsu, LY
    Koh, TH
    Anantham, D
    Kurup, A
    Chan, KPW
    Tan, BH
    [J]. EMERGING INFECTIOUS DISEASES, 2004, 10 (08) : 1509 - 1510
  • [3] Panton-Valentine leukocidin-positive Staphylococcus aureus and foreign travel
    Helgason, Kristjan O.
    Jones, Michael E.
    Edwards, Giles
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (02) : 832 - 833
  • [4] Panton-Valentine Leukocidin-Positive Staphylococcus aureus Skin Infections
    Mimica, Marcelo J.
    [J]. CLINICAL INFECTIOUS DISEASES, 2012, 54 (10) : 1517 - 1518
  • [5] Panton-Valentine Leukocidin-Positive Staphylococcus aureus Skin Infections Reply
    Zanger, Philipp
    Nurjadi, Dennis
    Schleucher, Regina
    Scherbaum, Helmut
    Wolz, Christiane
    Kremsner, Peter G.
    Schulte, Berit
    [J]. CLINICAL INFECTIOUS DISEASES, 2012, 54 (10) : 1518 - 1519
  • [6] Brain Abscess due to Panton-Valentine Leukocidin-Positive Staphylococcus aureus
    Ramos, A.
    Ley, L.
    Munez, E.
    Videl, A.
    Sanchez, I.
    [J]. INFECTION, 2009, 37 (04) : 365 - 367
  • [7] Panton-Valentine Leukocidin-Positive Staphylococcus aureus in Family and Pet Cat
    Bethe, Astrid
    Schink, Anne-Kathrin
    Brombach, Julian
    Epping, Lennard
    Semmler, Torsten
    Reinhardt, Susanne
    Molitor, Ernst
    Mueller, Svenja
    Balks, Julian
    Koeck, Robin
    Schwarz, Stefan
    Walther, Birgit
    Luebke-Becker, Antina
    [J]. EMERGING INFECTIOUS DISEASES, 2024, 30 (08)
  • [8] Disseminated Panton-Valentine Leukocidin-Positive Staphylococcus aureus infection in a child
    Karli, Arzu
    Yanik, Keramettin
    Paksu, Muhammet S.
    Sensoy, Gulnar
    Aykanat, Alper
    Yener, Nazik
    Belet, Nursen
    Ceyhan, Meltem
    [J]. ARCHIVOS ARGENTINOS DE PEDIATRIA, 2016, 114 (02): : E75 - E77
  • [9] Panton-Valentine Leukocidin-positive methicillin-resistant Staphylococcus aureus lung infection in patients with cystic fibrosis
    Elizur, Arnon
    Orscheln, Rachel C.
    Ferkol, Thomas W.
    Atkinson, Jeffrey J.
    Dunne, W. Michael, Jr.
    Buller, Richard S.
    Armstrong, Jon R.
    Mardis, Elaine R.
    Storch, Gregory A.
    Cannon, Carolyn L.
    [J]. CHEST, 2007, 131 (06) : 1718 - 1725
  • [10] Isolated hemorrhagic pleurisy due to Panton-Valentine leukocidin-positive Staphylococcus aureus
    El Ouafi, Z.
    Le Coustumier, E. -M.
    Fauchais, A. -L.
    Ly, K.
    Bezanahary, H.
    Barraud, O.
    Cypierre, A.
    [J]. REVUE DES MALADIES RESPIRATOIRES, 2019, 36 (03) : 359 - 363
12345