Conducting psychotherapy with adolescents is qualitatively different from psychotherapy with adults. Cognitive-behavioral therapy and dialectical behavior therapy are two types of psychotherapy commonly used in the treatment of adolescents. A brief review of the current state of research on these treatments is provided with a focus on anxiety disorders and depressive disorders. This article also describes adaptations of these treatments that will help the general psychiatrist to effectively conduct these treatments with adolescents in their practice.