Synthesis of thiourea derivatives of the alkaloid anabasine and crystal structure of N-(anabasino-1-thiocarbonyl)furan-2-carboxamide

被引：15
|
作者：
Kulakov, I. V. [1 ]
Nurkenov, O. A. [1 ]
Turdybekov, D. M. [2 ]
Ibragimov, B. T. [3 ]
Talipov, S. A. [3 ]
Zhambekov, Z. M. [1 ]
Ainabaev, A. A. [1 ]
Turdybekov, K. M. [2 ]
机构：
[1] Inst Organ Synth & Carbon Chem Republ Kazakhstan, Karaganda 100008, Kazakhstan
[2] Sci Prod Ctr Fitokhimiya, Karaganda 100009, Kazakhstan
[3] Inst Bioorgan Chem, Tashkent 100125, Uzbekistan
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2009年 / 45卷 / 02期
关键词：
alkaloid anabasine; thiourea derivatives; isothiocyanates; PMR spectroscopy; x-ray structure analysis; antibacterial activity;
D O I：
10.1007/s10600-009-9284-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of new N-acylsubstituted thioureas, the compositions and structures of which were determined by IR and PMR spectroscopy and mass spectrometry, were synthesized from the alkaloid anabasine. The crystal structure of one of the products, N-(anabasino-1-thiocarbonyl)furan-2-carboxamide, was confirmed by x-ray structure analysis. It was also shown that this compound exhibited moderate antibacterial activity.
引用
收藏
页码：209 / 212
页数：4
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