(Pre-)Osteoclasts induce retraction of osteoblasts before their fusion to osteoclasts

被引：45

作者：

Perez-Amodio, S

Beertsen, W

Everts, V

机构：

[1] Free Univ Amsterdam, Acad Ctr Dent Amsterdam, Dept Cell Biol, NL-1081 BT Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Acad Ctr Dent Amsterdam, Dept Cell Biol, NL-1081 BT Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1081 BT Amsterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1081 BT Amsterdam, Netherlands

[5] Univ Amsterdam, Acad Ctr Dent Amsterdam, Dept Oral Cell Biol, NL-1081 BT Amsterdam, Netherlands

[6] Vrije Univ Amsterdam, Acad Ctr Dent Amsterdam, Dept Oral Cell Biol, NL-1081 BT Amsterdam, Netherlands

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 10期

关键词：

matrix metalloproteinases; transforming growth factor-beta; osteoblast; fibroblast; pre-osteoclast;

D O I：

10.1359/JBMR.040509

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Precursors of osteoclasts seeded on top of a confluent layer of osteoblasts/bone lining cells induced retraction of the latter cells. The (pre)osteoclasts then migrated in the formed cell-free areas and fused to form osteoclast-like cells. Retraction of the osteoblasts/bone lining cells proved to depend on activity of matrix metalloproteinases, and TGF-beta1 prevented the retraction.

引用

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页码：1722 / 1731

页数：10

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