Metal resistance in yeast mediated by the expression of a maize 20S proteasome α subunit

被引：19
|
作者：
Forzani, C [1 ]
Lobréaux, S [1 ]
Mari, S [1 ]
Briat, JF [1 ]
Lebrun, M [1 ]
机构：
[1] Univ Montpellier 2, CNRS UMR 5004, Lab Biochim & Physiol Mol Plantes, F-34050 Montpellier 1, France
来源：
GENE | 2002年 / 293卷 / 1-2期
关键词：
nickel; stress; protein degradation; Saccharomyces cerevisiae;
D O I：
10.1016/S0378-1119(02)00758-8
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Transformation of yeast cells with a maize cDNA ZmPAA, encoding a 20S proteasome alpha-subunit, conferred resistance to nickel, cadmium and cobalt. This resistance is not linked to a modification of the intracellular nickel content, as no accumulation of nickel was measured between yeast cells transformed with a void vector or the ZmPAA cDNA. The abundance of the ZmPAA mRNA was increased in the shoots of maize plants upon nickel treatment. These results suggest that the proteasome might be involved in nickel resistance by scavenging metal oxidized proteins both in plants and yeast. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：199 / 204
页数：6
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