Follow-up of children with autoimmune hepatitis treated with cyclosporine

被引:69
|
作者
Cuarterolo, Miriam
Ciocca, Mirta
Canero Velasco, Cristina
Ramonet, Margarita
Gonzalez, Teresita
Lopez, Susana
Garsd, Armando
Alvarez, Fernando
机构
[1] Hosp Juan P Garrahan, Gastroenterol Unit, RA-1245 Buenos Aires, DF, Argentina
[2] Hosp Nino San Justo, Gastroenterol Unit, Buenos Aires, DF, Argentina
[3] Hosp Alejandro Posadas, Pediat Hepatol Unit, Buenos Aires, DF, Argentina
[4] Hosp Sor Maria Ludovica, Gastroenterol Unit, La Plata, Argentina
[5] Hollis Eden Pharmaceut Inc, San Diego, CA USA
[6] Univ Montreal, Hop St Justine, Gastroenterol Unit, Montreal, PQ H3T 1C5, Canada
关键词
autoimmune hepatitis; cyclosporine; treatment; prognosis;
D O I
10.1097/01.mpg.0000235975.75120.38
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objectives: To evaluate the effectiveness of cyclosporine in, inducing and maintaining remission of the inflammatory process in autoinumme hepatitis, when used in combination with low doses of prednisone and azathioprine and to identify the prognostic factors associated with sustained remission. Methods: Eighty-four patients with autoimmune hepatitis were consecutively recruited from 5 centers between January 1994 and March 2001. Cyclosporine was administered during the first 6 months. Thereafter, in patients with aminotransferase levels of lower than twice the normal values, prednisone and azathioprine were initiated. Results: Normal aminotransferase levels were observed in 94.05% (79/84) of the patients, 72% of them within the first 6 months of treatment. Total serum bilirubin level of greater than 1.2 mg/dL and portal hypertension at diagnosis jointly predicted a significant delay in remission. Adverse effects related to cyclosporine remained mild and transient. Low doses of prednisone and standard doses of azathioprine were not implicated in relapse of the disease during the follow-up of any patient. Conclusions: This protocol allowed control of the liver inflammatory process and was well tolerated. The response to this immunosuppressive therapy can be predicted with accuracy. Factors delaying remission can be identified early at diagnosis and may contribute to the development of more effective treatment policies for this condition.
引用
收藏
页码:635 / 639
页数:5
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