Synthesis of 6-Fluoroalkyl 6H-Benzo[c]chromenes via Visible-Light-Promoted Radical Addition/Cyclization of Biaryl Vinyl Ethers

被引：27

作者：

Deng, Qinfei ^{[1
]}

Tan, Liping ^{[1
]}

Xu, Yan ^{[1
]}

Liu, Ping ^{[1
]}

Sun, Peipei ^{[1
]}

机构：

[1] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Jiangsu, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 11期

基金：

中国国家自然科学基金;

关键词：

DIRECT ARYLATION; PHOTOREDOX CATALYSIS; CYCLIZATION REACTION; ORGANIC-SYNTHESIS; ROOM-TEMPERATURE; PALLADIUM; ARENES; FUNCTIONALIZATION; BENZOCHROMENES; CANNABINOIDS;

D O I：

10.1021/acs.joc.8b01149

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel visible-light-promoted cascade cyclization reaction for the synthesis of 6-fluoroalkyl 6H-benzo[c]-chromenes has been successfully realized, which was initiated by intermolecular radical addition to biaryl vinyl ethers using easily available fluoroalkylated reagents BrCF2CO2Et or 2-bromo-2,2-difluoroamides as the sources of fluorinated radicals, followed by the cyclization onto an aromatic ring process. This protocol tolerated a wide range of functional groups and provided the desired products in moderate to good yields.

引用

页码：6151 / 6161

页数：11

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