A FRET-based ratiometric fluorescent probe for visualizing H2S in lysosomes

被引：37
|
作者：
Zhang, Jie [1 ]
Wang, Runyu [2 ,3 ,4 ]
Zhu, Zhentao [1 ]
Yi, Long [1 ,4 ]
Xi, Zhen [2 ,3 ,4 ]
机构：
[1] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China
[2] Nankai Univ, State Key Lab Elemento Organ Chem, Tianjin 300071, Peoples R China
[3] Nankai Univ, Natl Pesticide Engn Res Ctr, Dept Biol Chem, Tianjin 300071, Peoples R China
[4] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China
来源：
TETRAHEDRON | 2015年 / 71卷 / 45期
基金：
美国国家科学基金会;
关键词：
H2S; FRET; Ratiometric detection; Fluorescent probe; Lysosomes; ENDOGENOUS HYDROGEN-SULFIDE; LIVING CELLS; MOUSE HIPPOCAMPUS;
D O I：
10.1016/j.tet.2015.09.028
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Hydrogen sulfide (H2S) is an endogenously produced gaseous signaling molecule with multiple biological functions. In order to detect the biological H2S, here a new FRET-based ratiomatric fluorescent probe was designed and synthesized for visualization of H2S in lysosomes. The probe displays good solubility, a marked yellow to blue emission color change in response of H2S and high H2S selectivity. Moreover, the probe could be used to detect of H2S in lysosomes with good biocompatibility. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8572 / 8576
页数：5
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