SPHINGOMYELIN CONTENT AFFECTS THE ACTIVITY OF MEMBRANE-BOUND ALKALINE PHOSPHATASE

被引：0
|
作者：
Petkova, Diana [1 ]
Pankov, Roumen [2 ]
Markovska, Tania [1 ]
Staneva, Galya [1 ]
Stefanova, Nadezhda [1 ]
Ivanova, Lidia [1 ]
Momchilova, Albena [1 ]
机构：
[1] Bulgarian Acad Sci, Inst Biophys, BU-1113 Sofia, Bulgaria
[2] St Kl Ohridski Sofia Univ, Fac Biol, Sofia, Bulgaria
来源：
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES | 2009年 / 62卷 / 04期
关键词：
alkaline phosphatase; phospholipids; sphingomyelin; sphingomyelinase; CELLS; FIBROBLASTS;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The dependence of membrane-bound alkaline phosphatase on the content of membrane sphingomyelin has been investigated. The level of membrane sphingomyelin has been manipulated by means of exogenous sphingomyelinase, which hydrolysed sphingomyelin molecules, yielding ceramide as a product. The results showed that the reduction of the level of membrane sphingomyelin was accompanied by a corresponding decrease of alkaline phosphatase activity, implying that this membrane-bound enzyme depends on the cellular sphingomyelin content.
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页码：469 / 472
页数：4
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