An efficient synthesis of cyanamide from amine promoted by a hypervalent iodine(III) reagent

被引：48

作者：

Ghosh, Harisadhan ^{[1
]}

Yella, Ramesh ^{[1
]}

Ali, Abdur Rezzak ^{[1
]}

Sahoo, Santosh K. ^{[1
]}

Patel, Bhisma K. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Gauhati 781039, Assam, India

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 20期

关键词：

TRANSFORMATION; DERIVATIVES; CHEMISTRY; MILD;

D O I：

10.1016/j.tetlet.2009.03.017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In a one-pot strategy we have achieved an efficient method for the synthesis of organic cyanamides starting from dithiocarbamic acid salts/amines. In this strategy the in situ generated alkyl or aryl isothiocyanates, obtained by the desulfurization of dithiocarbamic acid salts with diacetoxyiodobenzene (DIB) react with aqueous ammonia forming alkyl OF aryl thiourea which on subsequent oxidative desulfurization with DIB led to the formation of corresponding cyanamide in good yields. Mild reaction conditions, shorter reaction time, an environmentally benign protocol, and easy isolation of the desired product make the present methodology a Suitable alternative for the preparation of various organic cyanamides. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2407 / 2410

页数：4

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