Replication of murine coronaviruses in mouse embryonic stem cell lines in vitro

被引：12
|
作者：
Kyuwa, S
机构：
[1] Department of Animal Pathology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108
来源：
EXPERIMENTAL ANIMALS | 1997年 / 46卷 / 04期
关键词：
embryonic stem cells; mouse hepatitis virus; viral replication;
D O I：
10.1538/expanim.46.311
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Replication of murine coronaviruses in eight mouse embryonic stem (ES) cell lines of several genetic backgrounds was examined. Both mouse hepatitis virus (MHV) type 2 and MHV, strain A59 replicated well with no or minimal cytopathic effect in all the ES cell lines tested The results suggest the possibility that MHV-infected ES cells may disseminate MHV in mouse colonies due to embryo manipulation.
引用
收藏
页码：311 / 313
页数：3
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