Brain microvascular endothelial cells resist elongation due to curvature and shear stress

被引：95

作者：

Ye, Mao ^{[1
,2
]}

Sanchez, Henry M. ^{[2
,3
]}

Hultz, Margot ^{[2
,3
]}

Yang, Zhen ^{[4
]}

Bogorad, Max ^{[2
,3
]}

Wong, Andrew D. ^{[2
,3
]}

Searson, Peter C. ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Dept Phys & Astron, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Inst Nanobiotechnol INBT, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA

[4] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA

来源：

SCIENTIFIC REPORTS | 2014年 / 4卷

关键词：

PHENOTYPIC HETEROGENEITY; MICROFILAMENT BUNDLES; MECHANOTRANSDUCTION; BARRIER; SHAPE; EPITHELIOCYTES; MORPHOLOGY; PATTERNS;

D O I：

10.1038/srep04681

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The highly specialized endothelial cells in brain capillaries are a key component of the blood-brain barrier, forming a network of tight junctions that almost completely block paracellular transport. In contrast to vascular endothelial cells in other organs, we show that brain microvascular endothelial cells resist elongation in response to curvature and shear stress. Since the tight junction network is defined by endothelial cell morphology, these results suggest that there may be an evolutionary advantage to resisting elongation by minimizing the total length of cell-cell junctions per unit length of vessel.

引用

页数：6

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