Novel class of indole-2-carboxylates as potent glycine site NMDA antagonists.

被引:0
|
作者
DiFabio, R [1 ]
Araldi, G [1 ]
Giacobbe, S [1 ]
Pentassuglia, G [1 ]
Bozzoli, A [1 ]
Cimarosti, Z [1 ]
Maragni, P [1 ]
Rossi, T [1 ]
Reggiani, A [1 ]
机构
[1] GLAXOWELLCOME SPA,MED RES CTR,I-37100 VERONA,ITALY
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:178 / MEDI
页数:1
相关论文
共 50 条
  • [1] Novel substituted indole-2-carboxylates as potent glycine antagonists
    DiFabio, R
    Cugola, A
    Donati, D
    Feriani, A
    Gaviraghi, G
    Ratti, E
    Trist, D
    Reggiani, A
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 211 : 107 - MEDI
  • [2] Substituted indole-2-carboxylates as potent antagonists of the glycine binding site associated with the NMDA receptor
    Micheli, F
    Di Fabio, R
    Baraldi, D
    Conti, N
    Cugola, A
    Gastaldi, P
    Giacobbe, S
    Marchioro, C
    Mugnaini, M
    Rossi, L
    Pecunioso, A
    Pentassuglia, G
    [J]. ARCHIV DER PHARMAZIE, 1999, 332 (08) : 271 - 278
  • [3] Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site
    DiFabio, R
    Capelli, AM
    Conti, N
    Cugola, A
    Donati, D
    Feriani, A
    Gastaldi, P
    Gaviraghi, G
    Hewkin, CT
    Micheli, F
    Missio, A
    Mugnaini, M
    Pecunioso, A
    Quaglia, AM
    Ratti, E
    Rossi, L
    Tedesco, G
    Trist, DG
    Reggiani, A
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (06) : 841 - 850
  • [4] Synthesis and pharmacological characterisation of a conformationally restrained series of indole-2-carboxylates as in vivo potent glycine antagonists
    Di Fabio, R
    Araldi, G
    Baraldi, D
    Cugola, A
    Donati, D
    Gastaldi, P
    Giacobbe, SA
    Micheli, F
    Pentassuglia, G
    [J]. FARMACO, 2001, 56 (10): : 791 - 798
  • [5] INDOLE-2-CARBOXYLATES, NOVEL ANTAGONISTS OF THE N-METHYL-D-ASPARTATE (NMDA)-ASSOCIATED GLYCINE RECOGNITION SITES - INVIVO CHARACTERIZATION
    RAO, TS
    GRAY, NM
    DAPPEN, MS
    CLER, JA
    MICK, SJ
    EMMETT, MR
    IYENGAR, S
    MONAHAN, JB
    CORDI, AA
    WOOD, PL
    [J]. NEUROPHARMACOLOGY, 1993, 32 (02) : 139 - 147
  • [6] Cycloalkyl indole-2-carboxylates as useful tools for mapping the "North-Eastern" region of the glycine binding site associated with the NMDA receptor
    Micheli, F
    Di Fabio, R
    Capelli, AM
    Cugola, A
    Curcuruto, O
    Feriani, A
    Gastaldi, P
    Gaviraghi, G
    Marchioro, C
    Orlandi, A
    Pozzan, A
    Quaglia, AM
    Reggiani, A
    van Amsterdam, F
    [J]. ARCHIV DER PHARMAZIE, 1999, 332 (03) : 73 - 80
  • [7] Synthesis of tricyclic indole-2-caboxylic acids as potent NMDA-glycine antagonists. (vol 66, pg 3474, 2001)
    Katayama, S
    Ae, N
    Nagata, R
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (13): : 4742 - 4742
  • [8] SAR and neuroprotective activity of a novel class of glycine antagonists.
    Di Fabio, R
    Antolini, M
    Bertani, B
    Conti, N
    Donati, D
    Feriani, A
    Messeri, T
    Missio, A
    Pasquarello, A
    Pentassuglia, G
    Quaglia, A
    Reggiani, A
    Sabbatini, F
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 217 : U1238 - U1238
  • [9] Synthesis of tricyclic indole-2-caboxylic acids as potent NMDA-glycine antagonists
    Katayama, S
    Ae, N
    Nagata, R
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (10): : 3474 - 3483
  • [10] 2-aryl pyridazinoquinolinediones: Novel glycine site NMDA antagonists with potent in vitro and in vivo properties.
    Bare, TM
    Sparks, RB
    SchrefflerSmith, CN
    Empfield, JR
    Forst, JM
    Pastore, WM
    Rhile, IJ
    Pullan, LM
    Goldstein, JM
    Patel, JB
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 211 : 39 - MEDI